Career advice - even if it's one of the most required - is one of the hardest, and maybe, the most absurd genres to counsel. We are all so different and diverse, and so are our backgrounds and realities and expectations, that there is not such as a general career advice rule's sheet.

But if, gun to my face, I had to set up a list of the wiser and more valuable factors to take into

Not to be discussed that Purpose is a universal human need, as Joseph P. Carter highlights in his magnificent article: "without it, we feel bereft of meaning and happiness".

But

The Simon's Sinek Golden Circle it's not exactly a novelty, it's been around for a while.

It's old, but it doesn't get old. 

It clearly explains that the way to do it it's inside out, not otherwise.
Start with the WHY, and the HOW and the WHAT will